Topoisomerase 2 alpha

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August undefined, 2024

WebDoussis-Anagnostopoulou IA, Vassilakopoulos TP, Thymara I, et al. Topoisomerase II alpha expression as an independent prognostic factor in Hodgkin’s lymphoma. Clin Cancer Res. … WebTopoisomerase II alpha promotes gallbladder cancer proliferation and metastasis through activating phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin …

Expression of Topoisomerase II-α in Triple Negative Breast Cancer

WebTopoisomerase II alpha is a potential target for the treatment of human diseases such as breast cancer. In this article, we attempted to discover a novel anticancer drug. We have … DNA topoisomerase IIα is a human enzyme encoded by the TOP2A gene. Topoisomerase IIα relieves topological DNA stress during transcription, condenses chromosomes, and separates chromatids. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands … See more TOP2A has been shown to interact with SMURF2, HDAC1, CDC5L, Small ubiquitin-related modifier 1, P53, and TOPBP1. See more In Drosophila Hadlaczky et al 1988 found DNA topoisomerase II α to correlate with cell proliferation - but β did not. See more • Watt PM, Hickson ID (November 1994). "Structure and function of type II DNA topoisomerases". The Biochemical Journal. 303 (Pt 3): 681–695. doi:10.1042/bj3030681 See more • Topoisomerase II • TOP2B - Topoisomerase II beta • Gene duplication • Ataxia-telangiectasia See more fast loans poor credit

Human DNA topoisomerase II-alpha: a new marker of cell

WebEuropium-labeled mouse monoclonal antibody recognizing human DNA Topoisomerase 2-alpha phosphorylated at Thr1342. Sequence motif recognized: DEK(pT)DDE WebNov 11, 2015 · DNA topoisomerase 2 alpha (TOP2A) is an essential nuclear enzyme, required for resolution of topological stress associated with DNA replication. TOP2A introduces transient double strand breaks (DSB) on DNA in an ATP-dependent fashion to allow changes in DNA topology and eliminate over-winding [1,2]. TOP2A function is crucial … WebThe chromosome scaffold is a structural and organizational component of mitotic chromosomes. It comprises proteins that occupy the chromatid core and display a … french occupation of germany 1923

The prognostic significance of topoisomerase II alpha …

Type II topoisomerase - Wikipedia

WebMar 27, 2024 · Topoisomerase II alpha (TOP2A) protein has been shown to be a proliferation marker associated with tumor grade and Ki67 index. The prognostic effect of … WebMar 21, 2024 · TOP2A (DNA Topoisomerase II Alpha) is a Protein Coding gene. Diseases associated with TOP2A include Malignant Peripheral Nerve Sheath Tumor and … fast loans same day no creditWebThe topo II-alpha index correlates better with the MIB1 index than with the S-phase fraction or mitotic index. The topo II-alpha expression in breast cancer ranges from low (topo II-alpha index <1) to high (topo II-alpha index = 86). Amplification of c-erbB-2 was observed in 4 of 28 cases (14%) but did not correlate with high topo II-alpha indices. fast loans online for bad credit

"WebControl of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. ... " - Topoisomerase 2 alpha

Topoisomerase 2 alpha

WebMay 5, 2014 · cancer agent to target human DNA topoisomerase 2-alpha. Lalit Mohan Nainwal 1, Pratap Parida 2, Aparoo p Das 1 and ParthaSarathi Bairy 1. 1 Department of Pharmaceutical Sciences, ... WebJun 15, 2012 · To better understand how these enzymes act in both contexts, we determined the 2.9-Å-resolution structure of the DNA …

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WebProtein target information for DNA topoisomerase 2-alpha (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments. Webtopoisomerase (DNA) II alpha nucleus, response to DNA damage stimulus, nucleotide binding, nucleoplasm, ATP binding, protein complex, DNA binding, nucleolus, positive regulation of apoptotic process, protein homodimerization activity, drug binding, metal ion binding, magnesium ion binding, sequence-specific DNA binding, positive regulation of …

WebAnti-Topoisomerase II alpha antibody [EP1102Y] (ab52934) Research with confidence – consistent and reproducible results with every batch. Long-term and scalable supply – powered by recombinant technology for fast … WebNov 11, 2015 · DNA topoisomerase 2 alpha (TOP2A) is an essential nuclear enzyme, required for resolution of topological stress associated with DNA replication. TOP2A …

WebMar 9, 2024 · DNA topoisomerase 2-alpha, DNA Topoisomerase II alpha, DNA topoisomerase II, alpha isozyme. GeneRIFs: Gene References Into Functions. … WebTarget Information. Topo II alpha plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2 and M-phases in transformed and developmentally regulated normal cellsTopo II alpha is also implicated in drug resistance of tumor ...

WebAbstract. Topoisomerase II is a key target for several anti-cancer drugs used for breast cancer therapy, including doxorubicin, epirubicin and mitoxantrone. Two isoforms of topoisomerase II (alpha and beta) have been described in human cells which differ in their subcellular localisation, biochemical properties and susceptibility to inhibition ...

WebSep 1, 2015 · The aim of this study was to investigate association between expressions of multidrug resistance protein (MRP) and topoisomerase 2 alpha expression in non-small … fast loans same day near me fast loans no credit checksWebTarget Information. Topo II alpha plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and … french occupation of the rhineWebTopoisomerase II Alpha has been identified by DNA microarray and transcriptional profiling as a gene that is overexpressed in Cervical Carcinomas. The TOP2A gene is approximately 30 kb in size and encodes … french occupation of japanWebTopoisomerase Inhibitors. Compounds that inhibit the activity of DNA TOPOISOMERASES. A cytotoxic drug used as an adjunct for chemotherapy induction in the treatment of refractory childhood acute lymphoblastic leukemia. An antineoplastic enzyme inhibitor used to treat metastatic carcinoma of the colon or rectum. french occupationThere are two subclasses of type II topoisomerases, type IIA and IIB. • Type IIA topoisomerases include the enzymes DNA gyrase, eukaryotic topoisomerase II (topo II), and bacterial topoisomerase IV (topo IV). These enzymes span all domains of life and are essential for function. • Type IIB topoisomerases are structurally and biochemically distinct, and comprise a single family member, topoisomerase VI (topo VI). Type IIB topoisomerases are found in archae… french occupied germanyWebTopoisomerase 2 alpha (TOP2A) is considered to be the molecular target of these drugs. The potential predictive value of TOP2A amplification and overexpression has been extensively studied in breast cancer patients treated with anthracyclines. However, results are not conclusive. In this paper, we review some of the published studies addressing ... french occupation of algiers