Tertiapin
WebJan 1, 2011 · Tertiapin dose-dependently blunted the ACh-induced negative chronotropic response from an ACh-induced decrease in heart rate of 39±16% in control conditions to 3±3% after 300 nM tertiapin (P=0.01). WebBiological description. Potent blocker of inward rectifier K + channels. Stable analog of the bee venom tertiapin. High affinity for ROMK1 and GIRK1/4 (K. values are 1.3 and 13.3 nM, respectively). Displays >250-fold selectivity over many other Kir subtypes.
Tertiapin
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WebTertiapin, a short peptide from honey bee venom, has been reported to specifically block the inwardly rectifying K(+) (Kir) channels, including G protein-coupled inwardly rectifying potassium channel (GIRK) 1+GIRK4 heteromultimers and ROMK1 homomultimers. In the present study, the effects of a stabl … WebOct 8, 1999 · Tertiapin (TPN), a small protein derived from honey bee venom, inhibits the GIRK1/4 and ROMK1 channels with nanomolar affinities. Methionine residue 13 in TPN …
WebSep 1, 2006 · Tertiapin (4-41 nmol kg(-1), i.v.) terminated AF in the canine VNS-induced and aconitine-induced AF models. The muscarinic M-receptor antagonist AF-DX-116 terminated AF in these models, but the ... WebTertiapin-Q is a stable derivative of the bee venom toxin tertiapin. Tertiapin-Q binds to ROMK1 (K ir 1.1) and GIRK1/4 (K ir 3.1/3.4) channels with high affinity (K values are 1.3 …
WebTertiapin is a 21-amino acid peptide isolated from venom of the European honey bee . It blocks two different types of potassium channels, inward rectifier potassium channels and calcium activated large conductance potassium channels . WebTertiapin is a 21-amino acid peptide isolated from venom of the European honey bee . It blocks two different types of potassium channels, inward rectifier potassium channels …
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grin therapeutics incWebTertiapin Q is a peptide derivative of the honeybee venom peptide and inhibitor of inwardly rectifying potassium (K ir) channels, tertiapin. 1 It inhibits heteromultimeric potassium channels composed of G protein-activated inward rectifier potassium channel 1 (GIRK1) and GIRK4, also known as K ir 3.1 and K ir 3.4, respectively, as well as the inward-rectifier … fighting4fun vimeoWebAug 1, 2006 · Tertiapin terminated, in a dose-dependent manner, AF in VNS-induced AF models (Table 1). Tertiapin at higher dose (12 nmol kg −1) restored sinus rhythm in all dogs in 88 ± 22 s (n = 5). Developed AF (>1 min) could be reinduced in only one of five dogs after 12 nmol kg −1 of tertiapin. Tertiapin also terminated aconitine-induced AF. grint harry potterWebTertiapin (4-41 nmol kg(-1), i.v.) terminated AF in the canine VNS-induced and aconitine-induced AF models. The muscarinic M-receptor antagonist AF-DX-116 terminated AF in … fighting 4 freedomWebMar 18, 2008 · 텔티아핀(tertiapin) 0.1 %. 비만세포 탈과립작용. 프로카민(procamine) 1.4 %. 방사선 보호성과 관련성분. 알파-글루코시다제 (ɑ-glucosidase) 0.6 %. 항체역할 증진. 리소포스포리파제 (lysophospholipase) 1.0 %. 항체역할 증진 fighting4fun.comWebTertiapin-Q is an oxidation-resistant mutant of the wild-type tertiapin where Methionine 13 has been replaced by a Glutamine. Tertiapin-Q blocks the inwardly rectifying Kir1.1 … fighting 4 allWebAug 1, 2006 · @article{Hashimoto2006TertiapinAS, title={Tertiapin, a selective IKACh blocker, terminates atrial fibrillation with selective atrial effective refractory period prolongation.}, author={Norio Hashimoto and Toru Yamashita and Nobutomo Tsuruzoe}, journal={Pharmacological research}, year={2006}, volume={54 2}, pages={ 136-41 } } fight in flight characters