Biosynthesis of fungal meroterpenoids
WebApr 30, 2012 · Destroying aromaticity: A novel prenyltransferase (Trt2) involved in fungal meroterpenoid biosynthesis was shown to catalyze an unusual aromatic addition … WebStructure clarification of challengeable spiro-meroterpenoids with a 6/5/5 (7) ring system is of necessity because of their typical existence in Ganoderma. In this study, optically pure or impure nine meroterpenoids including seven new ones, spiroganodermaines H−J ( 1 , 4 and 5 ), spiroapplanatumine K ( 2 ), lucidumones I−K ( 7 – 9 ), and ...
Biosynthesis of fungal meroterpenoids
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WebMay 31, 2024 · The heterologous gene expression system with Aspergillus oryzae as the host is an effective method to investigate fungal secondary metabolite biosynthetic pathways for reconstruction to produce un-natural molecules due to its high productivity and genetic tractability. In this review, we focus on biosynthetic studies of fungal polyketide …
WebJul 31, 2024 · The recent elucidation of the biosynthetic pathways of several fungal meroterpenoids 7,8,9,10,11,12,13 indicated that their structural diversity is mainly attributed to the different terpene ... WebAug 1, 2010 · Among them, fungal meroterpenoids exhibit rich structural diversity with a wide range of biological activities 3 . In spite of their importance as potential therapeutic …
WebThe biosyntheses of 9, 10, 25–28, and 32 provide important insights into fungal meroterpenoid pathways that generate their structural diversity: the same intermediate can be cyclized into different compounds, and furthermore, the same or highly similar scaffolds can be tailored in versatile manners. 2.3. Biosynthesis of 15-deoxyoxalicines WebJun 16, 2024 · The heterologous gene expression system with Aspergillus oryzae as the host is an effective method to investigate fungal secondary metabolite biosynthetic pathways for reconstruction to produce un-natural molecules due to its high productivity and genetic tractability. In this review, we focus on biosynthetic studies of fungal polyketide …
WebJul 31, 2024 · Trt14 from Aspergillus terreus is involved in unusual skeletal reconstruction during the biosynthesis of the fungal meroterpenoid terretonin. Detailed in vitro characterization revealed that this novel multifunctional enzyme catalyzes not only the D-ring expansion via intramolecular methoxy rearrangement, but also the hydrolysis of the …
WebOct 1, 2024 · Fungal meroterpenoids are structurally diverse natural products with important biological activities. During their biosynthesis, α-ketoglutarate-dependent oxygenases (αKG-DOs) catalyze a wide range of chemically challenging transformation reactions, including desaturation, epoxidation, oxidative rearrangement, and … easthope car park church strettonWebApr 8, 2024 · C.-Y. Chiang, M. Ohashi, Y. Tang, Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining, Nat. Prod. Rep., 2024, 40, 89–127. Jo ur na l P re -p ro of Journal Pre-proof Ran Zou: Writing-Original draft preparation, Investigation. east hook farmhouse b \u0026 bWebFeb 13, 2012 · Meroterpenoids are a class of fungal natural products that are produced from polyketide and terpenoid precursors. An understanding of meroterpenoid biosynthesis at the genetic level should facilitate engineering of second-generation molecules and increasing production of first-generation compounds. cultist spawn eftWebDec 28, 2024 · In addition to the OA-derived meroterpenoids, mycophenolic acid, which is formed from 5-methylorsellinic acid (5-methyl-OA), has been clinically used as an important immunosuppressant drug [31, 32].Furthermore, many fungal meroterpenoids with complex and intriguing structures are generated from 3,5-dimethylorsellinic acid (3,5-dimethyl … east hoover avenueWebJan 11, 2024 · This study presents the extraordinary orthoester biosynthetic machinery and provides valuable insights into the creation of unnatural novel bioactive … east hoosuck massachusettsWebJun 1, 2024 · This information facilitates the manipulation of the enzyme reactions to create unnatural, novel molecules for drug discovery. This review summarizes recent progress in the structure-based engineering of αKG OX enzymes, involved in the biosynthesis of polyketide-derived fungal meroterpenoids. cultist spawn chance tarkovWebJul 2, 2024 · Genome Mining and Comparative Biosynthesis of Meroterpenoids from Two Phylogenetically Distinct Fungi Angew Chem Int Ed Engl. 2024 Jul 2;57 (27):8184 ... east hopei army